Chromatogram 1- Blank Plasma Sample

Bio-Analytical SPE Method For Quantitative Estimation

of Semaglutide

Quantitative Estimation of Semaglutide from Human K2 EDTA plasma samples

Semaglutide is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. It can be administered by subcutaneous injection or taken orally. It is sold under the brand names Ozempic and Rybelsus for diabetes, and under the brand name Wegovy for weight loss.

SEMAGLUTIDE

Table-1 Results

Chromatogram 2- LLOQ (1.0 ng/ml) overlay on Blank Plasma sample